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The potential of breath analysis to improve outcome for patients with lung cancer

Antoniou, S; Gaude, E; Ruparel, M; van der Schee, M; Janes, S; Rintoul, R; (2019) The potential of breath analysis to improve outcome for patients with lung cancer. Journal of Breath Research , 13 (3) , Article 034002. 10.1088/1752-7163/ab0bee. Green open access

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Abstract

Lung cancer remains the most common cause of cancer related death in both the UK and USA. Development of diagnostic approaches that have the ability to detect lung cancer early are a research priority with potential to improve survival. Analysis of exhaled breath metabolites, or volatile organic compounds (VOCs) is an area of considerable interest as it could fulfil such requirements. Numerous studies have shown that VOC profiles are different in the breath of patients with lung cancer compared to healthy individuals or those with non-malignant lung diseases. This review provides a scientific and clinical assessment of the potential value of a breath test in lung cancer. It discusses the current understanding of metabolic pathways that contribute to exhaled VOC production in lung cancer and reviews the research conducted to date. Finally, we highlight important areas for future research and discuss how a breath test could be incorporated into various clinical pathways.

Type: Article
Title: The potential of breath analysis to improve outcome for patients with lung cancer
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/1752-7163/ab0bee
Publisher version: https://doi.org/10.1088/1752-7163/ab0bee
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10069340
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