Ghohe, NM;
Tayebee, R;
Amini, MM;
Osatiashtiani, A;
Isaacs, MA;
Lee, AF;
(2017)
H5PW10V2O40@VOx/SBA-15-NH2 catalyst for the solventless synthesis of 3-substituted indoles.
Tetrahedron
, 73
(40)
pp. 5862-5871.
10.1016/j.tet.2017.08.030.
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H5PW10V2O40_VOx_SBA_15_NH2_catalyst_for_the_solventless_synthesis_of_3_.pdf - Accepted Version Download (2MB) | Preview |
Abstract
Functionalization of mesoporous SBA-15 frameworks by transition metal oxides offers a flexible route to fabricate new heterogeneous catalysts. Here, an inorganic-organic hybrid nanoporous catalyst H5PW10V2O40@VOx/SBA-15-NH2, was prepared and utilized as an efficient, eco-friendly, and recyclable catalyst for the one-pot, multi-component synthesis of 3-substituted indoles by indole substitution with aldehydes and malononitrile under solvent-free conditions. Catalysts were prepared by the non-covalent attachment of H5PW10V2O40 to a 3 wt%VOx/SBA-15 nanoporous support through a 3-(triethoxysilyl)propylamine linker. VOx/SBA-15 was prepared by a one-pot hydrothermal synthesis from TEOS and vanadium(V) oxytri-tert-butoxide [VO(O-tBu)3]. The resulting H5PW10V2O40@VOx/SBA-15-NH2 material was characterized by bulk and surface analysis including N2 porosimetry, FE-SEM, XRD, XPS, FT-IR, TGA-DTA, UV–Vis and ICP-OES, evidencing retention of the heteropolyacid Keggin structure. H5PW10V2O40@VOx/SBA-15-NH2 exhibits high activity and excellent yields (70–95%) of 3-substituted indoles under mild conditions, with negligible deactivation.
| Type: | Article |
|---|---|
| Title: | H5PW10V2O40@VOx/SBA-15-NH2 catalyst for the solventless synthesis of 3-substituted indoles |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.tet.2017.08.030 |
| Publisher version: | https://doi.org/10.1016/j.tet.2017.08.030 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Vanadia, SBA-15, Heteropolyacid, 3-Substituted indoles, Solventless |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10069241 |
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