UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients

Baraniak, I; Kern, F; Holenya, P; Griffiths, P; Reeves, M; (2019) Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients. Journal of Infectious Diseases , 220 (2) pp. 228-232. 10.1093/infdis/jiz089. Green open access

[thumbnail of Reeves_Original antigenic sin shapes the immunological repertoire evoked by HCMV gB-MF59 vaccine in seropositive patients_AAM.pdf]
Preview
Text
Reeves_Original antigenic sin shapes the immunological repertoire evoked by HCMV gB-MF59 vaccine in seropositive patients_AAM.pdf - Accepted Version

Download (2MB) | Preview

Abstract

A human cytomegalovirus (HCMV) vaccine is urgently needed to protect against primary infection and enhance existing immunity in HCMV-infected individuals (HCMV+). Using sera from HCMV+ glycoprotein B/MF59 vaccine recipients prior to transplant, we investigated the composition of the immune response. Vaccination boosted preexisting humoral responses in our HCMV+ cohort but did not promote de novo responses against novel linear epitopes. This suggests that prior natural infection has a profound effect on shaping the antibody repertoire and subsequent response to vaccination (“original antigenic sin”). Thus, vaccination of HCMV+ may require strategies of epitope presentation distinct from those intended to prevent primary infection.

Type: Article
Title: Original Antigenic Sin Shapes the Immunological Repertoire Evoked by Human Cytomegalovirus Glycoprotein B/MF59 Vaccine in Seropositive Recipients
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/infdis/jiz089
Publisher version: https://doi.org/10.1093/infdis/jiz089
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: cytomegalovirus, vaccination, antibody responses, original antigenic sin
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10068957
Downloads since deposit
50Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item