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Probing the Growth Kinetics for the Formation of Uniform 1D Block Copolymer Nanoparticles by Living Crystallization-Driven Self-Assembly

Boott, CE; Leitao, EM; Hayward, DW; Laine, RF; Mahou, P; Guerin, G; Winnik, MA; ... Manners, I; + view all (2018) Probing the Growth Kinetics for the Formation of Uniform 1D Block Copolymer Nanoparticles by Living Crystallization-Driven Self-Assembly. ACS Nano , 12 (9) pp. 8920-8933. 10.1021/acsnano.8b01353. Green open access

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Abstract

Living crystallization-driven self-assembly (CDSA) is a seeded growth method for crystallizable block copolymers (BCPs) and related amphiphiles in solution and has recently emerged as a highly promising and versatile route to uniform core–shell nanoparticles (micelles) with control of dimensions and architecture. However, the factors that influence the rate of nanoparticle growth have not been systematically studied. Using transmission electron microscopy, small- and wide-angle X-ray scattering, and super-resolution fluorescence microscopy techniques, we have investigated the kinetics of the seeded growth of poly(ferrocenyldimethylsilane)-b-(polydimethylsiloxane) (PFS-b-PDMS), as a model living CDSA system for those employing, for example, crystallizable emissive and biocompatible polymers. By altering various self-assembly parameters including concentration, temperature, solvent, and BCP composition our results have established that the time taken to prepare fiber-like micelles via the living CDSA method can be reduced by decreasing temperature, by employing solvents that are poorer for the crystallizable PFS core-forming block, and by increasing the length of the PFS core-forming block. These results are of general importance for the future optimization of a wide variety of living CDSA systems. Our studies also demonstrate that the growth kinetics for living CDSA do not exhibit the first-order dependence of growth rate on unimer concentration anticipated by analogy with living covalent polymerizations of molecular monomers. This difference may be caused by the combined influence of chain conformational effects of the BCP on addition to the seed termini and chain length dispersity.

Type: Article
Title: Probing the Growth Kinetics for the Formation of Uniform 1D Block Copolymer Nanoparticles by Living Crystallization-Driven Self-Assembly
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsnano.8b01353
Publisher version: https://doi.org/10.1021/acsnano.8b01353
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: block copolymers, self-assembly, nanofibers, crystallization, super-resolution fluorescence microscopy
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10068919
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