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Inflammatory demyelination without astrocyte loss in MOG antibody-positive NMOSD

Wang, JJ; Jaunmuktane, Z; Mummery, C; Brandner, S; Leary, S; Trip, SA; (2016) Inflammatory demyelination without astrocyte loss in MOG antibody-positive NMOSD. Neurology , 87 (2) pp. 229-231. 10.1212/WNL.0000000000002844.

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Abstract

We report a patient with neuromyelitis optica spectrum disorder (NMOSD) with antibodies against myelin oligodendrocyte protein (MOG) and seronegative for aquaporin-4 (AQP4) presenting with relapsing-remitting longitudinally extensive transverse myelitis (LETM) and cerebral tumefactive demyelinating lesions. Neuropathology showed active inflammatory demyelination with relative preservation of astrocytes.

Type: Article
Title: Inflammatory demyelination without astrocyte loss in MOG antibody-positive NMOSD
DOI: 10.1212/WNL.0000000000002844
Publisher version: https://doi.org/10.1212/WNL.0000000000002844
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, OPTICA SPECTRUM DISORDERS, NEUROMYELITIS-OPTICA
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10068878
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