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Best practice in Active Surveillance for men with prostate cancer: A Prostate Cancer UK consensus statement

Merriel, SWD; Hetherington, L; Seggie, A; Castle, JT; Cross, W; Roobol, MJ; Gnanapragasam, V; ... Prostate Cancer UK Expert Reference Group on Active Surveillance, ; + view all (2019) Best practice in Active Surveillance for men with prostate cancer: A Prostate Cancer UK consensus statement. BJU International , 124 pp. 47-54. 10.1111/bju.14707. Green open access

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Abstract

OBJECTIVES: To develop a consensus statement on current best practice of active surveillance (AS) in the UK, informed by patients and clinical experts. SUBJECTS AND METHODS: A consensus statement was drafted on the basis of three sources of data: systematic literature search of national and international guidelines; data arising from a Freedom of Information (FOI) Act request to UK urology departments regarding their current practice of AS; survey and interview responses from men with localised prostate cancer regarding their experiences and views of AS. The Prostate Cancer UK Expert Reference Group (ERG) on Active Surveillance was then convened to discuss and refine the statement. RESULTS: Guidelines and protocols for AS varied significantly in terms of risk stratification, criteria for offering AS, and protocols for AS between and within countries. Patients and healthcare professionals identified clinical, emotional and process needs for AS to be effective. Men with prostate cancer wanted more information and psychological support at the time of discussing AS with the treating team and in the first two years of AS, and a named healthcare professional to discuss any questions or concerns they had. The ERG agreed 30 consensus statements regarding best practice for AS. Statements were grouped under headings - 'Inclusion/Exclusion Criteria'; 'Active surveillance follow up protocol' and 'When to stop active surveillance'. CONCLUSION: Significant variation currently exists in the practice of AS in the UK and internationally. Men have clear views on the level of involvement in treatment decisions and support from their treating professionals when receiving AS. The Prostate Cancer UK AS ERG has developed a set of consensus statements for best practice in AS. Evidence for best practice in AS, and the use of multi-parametric magnetic resonance imaging (mpMRI) in AS, is still evolving, and further studies are needed to determine how to optimise AS outcomes. This article is protected by copyright. All rights reserved.

Type: Article
Title: Best practice in Active Surveillance for men with prostate cancer: A Prostate Cancer UK consensus statement
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/bju.14707
Publisher version: https://doi.org/10.1111/bju.14707
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: active surveillance, clinical consensus, guidelines, #PCSM, #ProstateCancer, #uroonc
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention
URI: https://discovery.ucl.ac.uk/id/eprint/10068858
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