UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A role for Dicer in immune regulation

Cobb, BS; Hertweck, A; Smith, J; O'Connor, E; Graf, D; Cook, T; Smale, ST; ... Merkenschlager, M; + view all (2006) A role for Dicer in immune regulation. Journal of Experimental Medicine , 203 (11) pp. 2519-2527. 10.1084/jem.20061692. Green open access

[thumbnail of A role for Dicer in immune regulation.pdf]
Preview
Text
A role for Dicer in immune regulation.pdf - Published Version

Download (1MB) | Preview

Abstract

Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor β. These results suggest that T reg cell development involves Dicer-generated RNAs.

Type: Article
Title: A role for Dicer in immune regulation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1084/jem.20061692
Publisher version: https://doi.org/10.1084/jem.20061692
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: foxp3 gene, micrornas, t-lymphocytes, helper-inducer t-lymphocytes, endoribonucleases, pancreatic ribonuclease, ribonucleases, enzymes, thymus gland, antigens, cd25
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Cancer Bio
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10068778
Downloads since deposit
48Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item