Cobb, BS;
Hertweck, A;
Smith, J;
O'Connor, E;
Graf, D;
Cook, T;
Smale, ST;
... Merkenschlager, M; + view all
(2006)
A role for Dicer in immune regulation.
Journal of Experimental Medicine
, 203
(11)
pp. 2519-2527.
10.1084/jem.20061692.
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Abstract
Micro RNAs (miRNAs) regulate gene expression at the posttranscriptional level. Here we show that regulatory T (T reg) cells have a miRNA profile distinct from conventional CD4 T cells. A partial T reg cell–like miRNA profile is conferred by the enforced expression of Foxp3 and, surprisingly, by the activation of conventional CD4 T cells. Depleting miRNAs by eliminating Dicer, the RNAse III enzyme that generates functional miRNAs, reduces T reg cell numbers and results in immune pathology. Dicer facilitates, in a cell-autonomous fashion, the development of T reg cells in the thymus and the efficient induction of Foxp3 by transforming growth factor β. These results suggest that T reg cell development involves Dicer-generated RNAs.
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