UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

A combined literature and in silico analysis enlightens the role of the NDRG family in the gut

Vaes, N; Schonkeren, SL; Brosens, E; Koch, A; McCann, CJ; Thapar, N; Hofstra, RMW; ... Melotte, V; + view all (2018) A combined literature and in silico analysis enlightens the role of the NDRG family in the gut. Biochimica et Biophysica Acta (BBA) - General Subjects , 1862 (10) pp. 2140-2151. 10.1016/j.bbagen.2018.07.004. Green open access

[img]
Preview
Text
McCann_A combined literature and in silico analysis enlightens the role of the NDRG family in the gut_AAM.pdf - Accepted version

Download (653kB) | Preview

Abstract

BACKGROUND: The N-Myc Downstream-Regulated Gene (NDRG) family comprises four members that function in cellular processes like proliferation and differentiation. While NDRG1 and NDRG2 are extensively studied, knowledge regarding NDRG3 and NDRG4, despite its recognition as a well-established early-detection marker for colorectal cancer (Cologuard®), is sparse. SCOPE OF REVIEW: To summarize expression, biomarker potential and functional mechanisms of the NDRGs in the developing, mature and cancerous gut, we combine current literature and in silico analyses from the TCGA-database, GTEX Project, E14.5 mouse intestine and enteric neural crest cells, and an RNA-sequencing time-series of human embryonic colonic samples. MAJOR CONCLUSIONS: This study reveals that all members display a differential expression pattern in the gut and that NDRG1, NDRG2 and NDRG4 (1) can serve as biomarker for colorectal cancer and (2) have tumor suppressive properties mainly affecting cell proliferation and epithelial-mesenchymal transition. GENERAL SIGNIFICANCE: Similar effects of the NDRGs on the key-hallmarks of cancer, could implicate analogous functions in other tissue/cancer types.

Type: Article
Title: A combined literature and in silico analysis enlightens the role of the NDRG family in the gut
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbagen.2018.07.004
Publisher version: https://doi.org/10.1016/j.bbagen.2018.07.004
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Biomarkers, Colorectal cancer, Intestinal tract, N-myc downstream-regulated gene, Tumor suppressors
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10068685
Downloads since deposit
165Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item