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Functional vision and cognition in infants with congenital disorders of the peripheral visual system

Dale, N; Sakkalou, E; O'Reilly, M; Springall, C; De Haan, M; Salt, A; (2017) Functional vision and cognition in infants with congenital disorders of the peripheral visual system. Developmental Medicine and Child Neurology , 59 (7) pp. 725-731. 10.1111/dmcn.13429. Green open access

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Abstract

Aim To investigate how vision relates to early development by studying vision and cognition in a national cohort of 1‐year‐old infants with congenital disorders of the peripheral visual system and visual impairment. Method This was a cross‐sectional observational investigation of a nationally recruited cohort of infants with ‘simple’ and ‘complex’ congenital disorders of the peripheral visual system. Entry age was 8 to 16 months. Vision level (Near Detection Scale) and non‐verbal cognition (sensorimotor understanding, Reynell Zinkin Scales) were assessed. Parents completed demographic questionnaires. Results Of 90 infants (49 males, 41 females; mean 13mo, standard deviation [SD] 2.5mo; range 7–17mo); 25 (28%) had profound visual impairment (light perception at best) and 65 (72%) had severe visual impairment (basic ‘form’ vision). The Near Detection Scale correlated significantly with sensorimotor understanding developmental quotients in the ‘total’, ‘simple’, and ‘complex’ groups (all p<0.001). Age and vision accounted for 48% of sensorimotor understanding variance. Infants with profound visual impairment, especially in the ‘complex’ group with congenital disorders of the peripheral visual system with known brain involvement, showed the greatest cognitive delay. Interpretation Lack of vision is associated with delayed early‐object manipulative abilities and concepts; ‘form’ vision appeared to support early developmental advance. This paper provides baseline characteristics for cross‐sectional and longitudinal follow‐up investigations in progress. A methodological strength of the study was the representativeness of the cohort according to national epidemiological and population census data.

Type: Article
Title: Functional vision and cognition in infants with congenital disorders of the peripheral visual system
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/dmcn.13429
Publisher version: https://doi.org/10.1111/dmcn.13429
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Pediatrics, Neurosciences & Neurology, YOUNG-CHILDREN, BLIND-CHILDREN, IMPAIRMENT, SETBACK, BABIES, PLAY, UK
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Developmental Neurosciences Prog
URI: https://discovery.ucl.ac.uk/id/eprint/10068661
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