Walker-Samuel, S;
Roberts, T;
Ramasawmy, R;
Burrell, J;
Johnson, P;
Siow, B;
Richardson, S;
... Lythgoe, M; + view all
(2017)
Investigating low-velocity fluid flow in tumours using convection-MRI.
BioRxiv: Cold Spring Harbor, NY, USA.
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Abstract
Several distinct fluid flow phenemena occur in solid tumours, including intravascular blood flow and interstitial convection. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we have developed a novel magnetic resonance imaging (MRI) technique named convection-MRI. It uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extra-vascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations and tumor xenograft models to investigate the technical feasibility of convection-MRI. We report a good correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive measurements of interstitial fluid pressure in mouse models of human colorectal carcinoma and show that convection-MRI can provide insights into the growth and response to vascular-targeting therapy in colorectal cancers.
Type: | Working / discussion paper |
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Title: | Investigating low-velocity fluid flow in tumours using convection-MRI |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1101/200279 |
Publisher version: | https://doi.org/10.1101/200279 |
Language: | English |
Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging |
URI: | https://discovery.ucl.ac.uk/id/eprint/10068589 |
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