Krishnamoorthy, S;
Kumaresan, N;
Zumla, A;
(2019)
Latent Tuberculosis Infection and renal transplantation - diagnosis and management.
International Journal of Infectious Diseases
10.1016/j.ijid.2019.01.049.
(In press).
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Abstract
BACKGROUND: Tuberculosis (TB) continues to be the commonest infectious disease cause of death worldwide. Tuberculosis is an important infectious disease cause of morbidity and death in renal transplant recipients. Tuberculosis can also cause loss of kidney allograft OBJECTIVES: The purpose of this viewpoint is to highlight the issues related to prevention, diagnosis and treatment of tuberculosis in renal transplant recipients. METHODS: The PubMed database was searched for publications and guidelines on diagnosis and management of LTBI in renal transplantation. Publications on renal allograft recipients with LTBI and TB in post-operative period were also analysed. Specialist Society guidelines were also used. FINDINGS: Tuberculosis is one of the most important infectious diseases related cause of morbidity and death in transplant recipients. LTBI in allograft recipients continues to be a clinical management problem. It can occur either from donor kidney or from endogenous reactivation of latent tuberculosis infection or acquiring new Mycobacterium tuberculosis infection. Tuberculosis can also cause loss of kidney allograft. CONCLUSIONS: Kidney transplantation is now universally performed in high and low Tuberculosis endemic countries. A high index of awareness of the possibility of TB disease or LTBI is required prior to renal transplant aligned to reduce renal allograft damage, morbidity and death due to tuberculous. WHO Management recommendations for LTBI screening and treatment should be followed.
| Type: | Article |
|---|---|
| Title: | Latent Tuberculosis Infection and renal transplantation - diagnosis and management |
| Location: | Canada |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijid.2019.01.049 |
| Publisher version: | http://doi.org/10.1016/j.ijid.2019.01.049 |
| Language: | English |
| Additional information: | This article is published under Attribution-Non Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) licence. |
| Keywords: | Interferon gamma assay, Latent tuberculosis infection (LTBI), Tuberculin skin test, allograft, immune suppression, renal transplantation |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10068451 |
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