UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Antibody based therapy for childhood solid cancers

Birley, K; Chester, K; Anderson, J; (2018) Antibody based therapy for childhood solid cancers. Current Opinion in Chemical Engineering , 19 pp. 153-162. 10.1016/j.coche.2018.01.005. Green open access

[img]
Preview
Text
Birley_johns edits Draft 1.pdf - Accepted version

Download (121kB) | Preview

Abstract

Antibody therapy for cancer has potential to combine specific targeting with a range of effector mechanisms to produce potent anti-tumor responses. Antibody-based treatments are growing in success for adult cancers but have shown limited efficacy for pediatric cancers. Pediatric solid tumors have a lower mutation load that their adult counterparts and pose a unique set of challenges compared to hematological malignancies and to adult solid tumors. Whilst a number of antibodies have been subject to clinical trials in pediatric patients the response tends to be limited and there is need to identify patients most likely to benefit. The role of antibodies in combination with conventional chemotherapy and new emerging therapies is a developing field that could provide new opportunities.

Type: Article
Title: Antibody based therapy for childhood solid cancers
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.coche.2018.01.005
Publisher version: https://doi.org/10.1016/j.coche.2018.01.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10067963
Downloads since deposit
43Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item