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Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literatureA report from the SIOP Renal Tumor Study Group

Hol, JA; van den Heuvel-Eibrink, MM; Graf, N; Pritchard-Jones, K; Brok, J; van Tinteren, H; Howell, L; ... Mavinkurve-Groothuis, AMC; + view all (2018) Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literatureA report from the SIOP Renal Tumor Study Group. Pediatric Blood & Cancer , 65 (2) , Article e26849. 10.1002/pbc.26849. Green open access

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Abstract

While irinotecan has been studied in various pediatric solid tumors, its potential role in Wilms tumor (WT) is less clear. We evaluated response and outcome of irinotecan‐containing regimens in relapsed WT and compared our results to the available literature. Among 14 evaluable patients, one complete response (CR) and two partial responses (PRs) were observed in patients with initial intermediate‐risk (CR and PR) and blastemal‐type histologies (PR). Two patients were alive at last follow‐up showing no evidence of disease. Our results and the reviewed literature suggest some effectiveness of irinotecan in the setting of relapsed WT.

Type: Article
Title: Irinotecan for relapsed Wilms tumor in pediatric patients: SIOP experience and review of the literatureA report from the SIOP Renal Tumor Study Group
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/pbc.26849
Publisher version: https://doi.org/10.1002/pbc.26849
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: irinotecan, pediatric solid tumors, relapsed Wilms tumor
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10067953
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