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Autophagy promotes visceral aging in wild-type C. elegans

Benedetto, A; Gems, D; (2019) Autophagy promotes visceral aging in wild-type C. elegans. Autophagy 10.1080/15548627.2019.1569919. (In press). Green open access

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Abstract

A plethora of studies over several decades has demonstrated the importance of autophagy in aging and age-related neurodegenerative disease. The role of autophagy in damage clearance and cell survival is well established, and supports a prevailing view that increasing autophagic activity can be broadly beneficial, and could form the basis of anti-aging interventions. However, macroautophagy/autophagy also promotes some elements of senescence. For example, in C. elegans hermaphrodites it facilitates conversion of intestinal biomass into yolk, leading to sex-specific gut atrophy and senescent steatosis.

Type: Article
Title: Autophagy promotes visceral aging in wild-type C. elegans
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/15548627.2019.1569919
Publisher version: http://doi.org/10.1080/15548627.2019.1569919
Language: English
Additional information: Copyright © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Aging, IIS, autophagy, intestine, lipoprotein, pathology, reproduction, sexual dimorphism, vitellogenin, yolk
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/10067907
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