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A Durable Porcine Pericardial Surgical Bioprosthetic HeartValve: a Proof of Concept

Rahmani, B; McGregor, C; Byrne, G; Burriesci, G; (2019) A Durable Porcine Pericardial Surgical Bioprosthetic HeartValve: a Proof of Concept. Journal of Cardiovascular Translational Research 10.1007/s12265-019-09868-3. (In press). Green open access

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Abstract

Bioprosthetic leaflets made from animal tissues are used in the majority of surgical and transcatheter cardiac valve replacements.This study develops a new surgical bioprosthesis, using porcine pericardial leaflets. Porcine pericardium was obtained fromgenetically engineered pigs with a mutation in the GGTA-1 gene (GTKO) and fixed in 0.6% glutaraldehyde, and used to developa new surgical valve design. The valves underwent in vitro hydrodynamic test in a pulse duplicator and high-cycled acceleratedwear testing and were evaluated for acute haemodynamics and thrombogenicity in a juvenile sheep implant study for 48 h. Theporcine surgical pericardial heart valves (pSPHVs) exhibited excellent hydrodynamics and reached 200 million cycles of in vitrodurability, with no observable damage. Juvenile sheep implants demonstrated normal valve function with no acute thrombogenicresponse for either material. The pSPHV incorporates a minimalistic construction method using a tissue-to-tissue design to coverthe stent. This new design is a proof of concept alternative to the use of bovine pericardium and synthetic fabric in surgicalbioprosthetic heart valves.

Type: Article
Title: A Durable Porcine Pericardial Surgical Bioprosthetic HeartValve: a Proof of Concept
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s12265-019-09868-3
Publisher version: https://doi.org/10.1007/s12265-019-09868-3
Language: English
Additional information: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/ licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
Keywords: Biological heart valve, Porcine pericardium, Xenotransplantation, Gal knockout, Calcification
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10067873
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