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Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary

Gaba, F; Piek, J; Menon, U; Manchanda, R; (2019) Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary. BJOG: An International Journal of Obstetrics and Gynaecology , 126 (7) pp. 831-839. 10.1111/1471-0528.15651. Green open access

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Abstract

Ovarian cancer (OC) is the leading cause of death from gynaecological malignancies in the UK. Despite considerable funding to develop new treatments, 10‐year survival remains poor at ~30%. This translates into 4,271 deaths annually in the UK, 42,700 in Europe and 152,000 deaths annually worldwide. High (e.g.‐BRCA1/BRCA2) and moderate (e.g.‐RAD51C/RAD51D/BRIP1) penetrance gene‐mutations account for most of the known hereditary‐risk of OC. At least 10% of women with epithelial‐OC carry these germline mutations.

Type: Article
Title: Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/1471-0528.15651
Publisher version: https://doi.org/10.1111/1471-0528.15651
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10067835
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