Gaba, F;
Piek, J;
Menon, U;
Manchanda, R;
(2019)
Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary.
BJOG: An International Journal of Obstetrics and Gynaecology
, 126
(7)
pp. 831-839.
10.1111/1471-0528.15651.
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Abstract
Ovarian cancer (OC) is the leading cause of death from gynaecological malignancies in the UK. Despite considerable funding to develop new treatments, 10‐year survival remains poor at ~30%. This translates into 4,271 deaths annually in the UK, 42,700 in Europe and 152,000 deaths annually worldwide. High (e.g.‐BRCA1/BRCA2) and moderate (e.g.‐RAD51C/RAD51D/BRIP1) penetrance gene‐mutations account for most of the known hereditary‐risk of OC. At least 10% of women with epithelial‐OC carry these germline mutations.
| Type: | Article |
|---|---|
| Title: | Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/1471-0528.15651 |
| Publisher version: | https://doi.org/10.1111/1471-0528.15651 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10067835 |
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