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Mechanisms of Neural Crest Migration

Szabo, A; Mayor, R; (2018) Mechanisms of Neural Crest Migration. Annual Review of Genetics , 52 pp. 43-63. 10.1146/annurev-genet-120417-031559.

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Abstract

Neural crest cells are a transient embryonic cell population that migrate collectively to various locations throughout the embryo to contribute a number of cell types to several organs. After induction, the neural crest delaminates and undergoes an epithelial-to-mesenchymal transition before migrating through intricate yet characteristic paths. The neural crest exhibits a variety of migratory behaviors ranging from sheet-like mass migration in the cephalic regions to chain migration in the trunk. During their journey, neural crest cells rely on a range of signals both from their environment and within the migrating population for navigating through the embryo as a collective. Here we review these interactions and mechanisms, including chemotactic cues of neural crest cells’ migration.

Type: Article
Title: Mechanisms of Neural Crest Migration
DOI: 10.1146/annurev-genet-120417-031559
Publisher version: http://doi.org/10.1146/annurev-genet-120417-031559
Language: English
Keywords: neural crest, collective cell migration, morphogenesis, contact inhibition of locomotion, chemotaxis, confinement
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10067384
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