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Emerging evidence of an effect of salt on innate and adaptive immunity

Evans, RDR; Antonelou, M; Henderson, S; Walsh, SB; Salama, AD; (2019) Emerging evidence of an effect of salt on innate and adaptive immunity. Nephrology Dialysis Transplantation , 34 (12) pp. 2007-2014. 10.1093/ndt/gfy362. Green open access

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Abstract

Salt intake as part of a western diet currently exceeds recommended limits, and the small amount found in the natural diet enjoyed by our Paleolithic ancestors. Excess salt is associated with the development of hypertension and cardiovascular disease, but other adverse effects of excess salt intake are beginning to be recognized, including the development of autoimmune and inflammatory disease. Over the last decade there has been an increasing body of evidence demonstrating that salt affects multiple components of both the innate and adaptive immune systems. In this review we outline the recent laboratory, animal and human data, highlighting the effect of salt on immunity, with a particular focus on the relevance to inflammatory kidney disease.

Type: Article
Title: Emerging evidence of an effect of salt on innate and adaptive immunity
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/ndt/gfy362
Publisher version: http://doi.org/10.1093/ndt/gfy362
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: glomerulonephritis, inflammation, macrophage, T cell, transplantation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Renal Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10067382
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