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In Vivo Imaging of CNS Injury and Disease

Akassoglou, K; Merlini, M; Rafalski, VA; Real, R; Liang, L; Jin, Y; Dougherty, SE; ... Zheng, B; + view all (2017) In Vivo Imaging of CNS Injury and Disease. The Journal of Neuroscience , 37 (45) pp. 10808-10816. 10.1523/JNEUROSCI.1826-17.2017. Green open access

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Abstract

In vivo optical imaging has emerged as a powerful tool with which to study cellular responses to injury and disease in the mammalian CNS. Important new insights have emerged regarding axonal degeneration and regeneration, glial responses and neuroinflammation, changes in the neurovascular unit, and, more recently, neural transplantations. Accompanying a 2017 SfN Mini-Symposium, here, we discuss selected recent advances in understanding the neuronal, glial, and other cellular responses to CNS injury and disease with in vivo imaging of the rodent brain or spinal cord. We anticipate that in vivo optical imaging will continue to be at the forefront of breakthrough discoveries of fundamental mechanisms and therapies for CNS injury and disease.

Type: Article
Title: In Vivo Imaging of CNS Injury and Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1523/JNEUROSCI.1826-17.2017
Publisher version: https://doi.org/10.1523/JNEUROSCI.1826-17.2017
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: blood-brain barrier, iPSCs, microglia, retina, two-photon imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10067148
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