UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Use of a water-based probiotic to treat common gut pathogens

Dodoo, CC; Stapleton, P; Basit, AW; Gaisford, S; (2019) Use of a water-based probiotic to treat common gut pathogens. International Journal of Pharmaceutics , 556 pp. 136-141. 10.1016/j.ijpharm.2018.11.075. Green open access

[thumbnail of Dodoo_IJP Symprove Pathogen - For submission R1.pdf]
Preview
Text
Dodoo_IJP Symprove Pathogen - For submission R1.pdf - Accepted Version

Download (1MB) | Preview

Abstract

This work reports the anti-pathogenic effect of a commercially available water-based probiotic suspension, Symprove™, against three commonly encountered infectious organisms; Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA) and Shigella sonnei. An isothermal calorimetric assay was used to the monitor growth of the species individually and in binary combinations, while colony plate counting was used to enumerate viable cell numbers. It was observed that all pathogenic species were faster growing than the probiotic bacteria in Symprove™ after inoculation into growth medium yet in all instances bacterial enumeration at the end of the experiments revealed a significant reduction in the pathogen population compared with the controls. A control population between 108 and 109 CFU/ml was obtained for E. coli and S. sonnei whilst approximately 106 CFU/ml was obtained for MRSA. Upon co-incubation for 48 h, no viable counts were obtained for E. coli; a 4-log reduction was obtained for S. sonnei whilst MRSA numbers were down to less than 10 cells/ml. The results show that Symprove™ has antipathogenic activity against E. coli, S. sonnei and MRSA.

Type: Article
Title: Use of a water-based probiotic to treat common gut pathogens
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ijpharm.2018.11.075
Publisher version: https://doi.org/10.1016/j.ijpharm.2018.11.075
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Infectious diseases, Lactobacilli, MRSA, Shigella sonnei, Escherichia coli
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10066716
Downloads since deposit
521Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item