UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI

Brogueira Rodrigues, FA; Byrne, L; De Vita, E; Johnson, E; Hobbs, N; Thornton, J; Scahill, R; (2019) Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI. European Journal of Neuroscience 10.1111/ejn.14356. (In press). Green open access

[img]
Preview
Text
Brogueira Rodrigues VoR 2019 01 Eur J Neurosci Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI.pdf - Published version

Download (375kB) | Preview

Abstract

Multiple targeted therapeutics for Huntington’s disease are now in clinical trials, including intrathecally-delivered compounds. Previous research suggests CSF dynamics may be altered in Huntington’s disease, which could be of paramount relevance to intrathecal drug delivery to the brain. To test this hypothesis we conducted a prospective cross-sectional study comparing people with early stage Huntington’s disease with age- and gender-matched healthy controls. CSF peak velocity, mean velocity and mean flow at the level of the cerebral aqueduct, and sub-arachnoid space in the upper and lower spine, were quantified using phase contrast MRI. We calculated Spearman’s rank correlations, and tested inter-group differences with Wilcoxon rank-sum test. Ten people with early Huntington’s disease, and 10 controls were included. None of the quantified measures was associated with potential modifiers of CSF dynamics (demographics, osmolality, and brain volumes), or by know modifiers of Huntington’s disease (age and CAG-repeat); and no significant differences were found between the two studied groups. While external validation is required, the attained results are sufficient to conclude tentatively that a clinically-relevant alteration of CSF dynamics – i.e. one that would justify dose-adjustments of intrathecal drugs – is unlikely to exist in Huntington’s disease.

Type: Article
Title: Cerebrospinal fluid flow dynamics in Huntington's disease evaluated by phase contrast MRI
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/ejn.14356
Publisher version: https://doi.org/10.1111/ejn.14356
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Huntington disease; Cerebrospinal Fluid; Magnetic Resonance Imaging; Humans
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10066656
Downloads since deposit
34Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item