UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence

Memar, N; Schiemann, S; Hennig, C; Findeis, D; Conradt, B; Schnabel, R; (2018) Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence. Developmental Biology 10.1016/j.ydbio.2018.12.022. (In press). Green open access

[img]
Preview
Text
1-s2.0-S0012160618306870-main.pdf - Published version

Download (2MB) | Preview

Abstract

The four Caenorhabditis species C. elegans, C. briggsae, C. remanei and C. brenneri show more divergence at the genomic level than humans compared to mice (Stein et al., 2003; Cutter et al., 2006, 2008). However, the behavior and anatomy of these nematodes are very similar. We present a detailed analysis of the embryonic development of these species using 4D-microscopic analyses of embryos including lineage analysis, terminal differentiation patterns and bioinformatical quantifications of cell behavior. Further functional experiments support the notion that the early development of all four species depends on identical induction patterns. Based on our results, the embryonic development of all four Caenorhabditis species are nearly identical, suggesting that an apparently optimal program to construct the body plan of nematodes has been conserved for at least 20 million years. This contrasts the levels of divergence between the genomes and the protein orthologs of the Caenorhabditis species, which is comparable to the level of divergence between mouse and human. This indicates an intricate relationship between the structure of genomes and the morphology of animals.

Type: Article
Title: Twenty million years of evolution: The embryogenesis of four Caenorhabditis species are indistinguishable despite extensive genome divergence
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ydbio.2018.12.022
Publisher version: http://doi.org/10.1016/j.ydbio.2018.12.022
Language: English
Additional information: Copyright © 2019 The Authors. Published by Elsevier Inc. This article is distributed under the terms of the Attribution-Non Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license.
Keywords: Caenorhabditis species, Embryogenesis, Evolutionary developmental biology (evo-devo), 4D microscopy, Bioinformatics, Cell lineage, Signaling pathway
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/10066535
Downloads since deposit
58Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item