Pollara, G;
Logan, S;
Collins, S;
Marks, M;
Underwood, J;
(2019)
Intravenous catheter-related adverse events exceed drug-related adverse events in outpatient parenteral antimicrobial therapy.
Journal of Antimicrobial Chemotherapy
, 74
(3)
pp. 787-790.
10.1093/jac/dky474.
Preview |
Text
Intravenous catheter-related adverse events exceed drug-related adverse events in outpatient parenteral antimicrobial therpay.pdf - Published Version Download (318kB) | Preview |
Abstract
Background Drug-related adverse events (AEs) are reported to be common amongst patients receiving outpatient parenteral antimicrobial therapy (OPAT). However, comparative data regarding intravenous (iv) catheter-related AEs are lacking. Objectives To compare drug- and iv catheter-related AEs from a large UK OPAT centre. Patients and methods We reviewed 544 OPAT episodes [median (IQR) age: 57 (39–71) years, 60% male, 13% with diabetes] with a median (IQR) duration of 7 (2–18) days. Clinically significant drug- and iv catheter-related AEs were calculated as a percentage of OPAT episodes with an AE and also as AEs per 1000 iv drug/catheter days. Results Drug-related AEs complicated 13 (2.4%) OPAT episodes at 1.7 (95% CI 0.9–2.9) per 1000 drug days. Catheter-related AEs occurred more frequently, complicating 32 (5.9%) episodes at 5.7 (95% CI 4.2–7.9) per 1000 iv catheter days (χ2 test for difference in AE rate: P < 0.001). Non-radiologically guided midline catheters were associated with the most frequent AEs (n = 23) at 15.6 (95% CI 10.3–23.4) per 1000 iv catheter days compared with other types of iv catheters (HR 8.4, 95% CI 2.4–51.9, P < 0.004), and self-administration was associated with a higher rate of catheter-related AEs at 12.0 (95% CI 6.0–23.9) per 1000 iv catheter days (HR 4.15, 95% CI 1.7–9.1, P = 0.007). Conclusions Clinically significant iv catheter-related AEs occurred more frequently than drug-related AEs, especially when using non-radiologically guided midline catheters. Regular review of the need for iv therapy and switching to oral antimicrobials when appropriate is likely to minimize OPAT-related AEs.
| Type: | Article |
|---|---|
| Title: | Intravenous catheter-related adverse events exceed drug-related adverse events in outpatient parenteral antimicrobial therapy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/jac/dky474 |
| Publisher version: | https://doi.org/10.1093/jac/dky474 |
| Language: | English |
| Additional information: | © The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10066483 |
Archive Staff Only
 |
View Item |
