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The role of the neuropilins in tumour angiogenesis and tumour progression

Liu, D; Mahmoud, M; Milagre, C; Zachary, I; Frankel, P; (2017) The role of the neuropilins in tumour angiogenesis and tumour progression. In: The Neuropilins: Role and Function in Health and Disease. (pp. 163-186). Springer: Cham, Switzerland. Green open access

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Abstract

Neuropilins (NRPs) are multifunctional receptors for class 3 semaphorins, which are responsible for axon guidance during the development of the nervous system in vertebrates, and for vascular endothelial growth factors (VEGFs), essential for vascular development and angiogenesis in disease. There is now a large body of evidence that NRPs also mediate tumour angiogenesis and progression, and they have also emerged as novel therapeutic targets in cancer. Many neoplastic cell types express NRPs, and NRP1 and NRP2 upregulation is positively correlated with tumour progression and poor patient prognosis in several cancer types (Pellet-Many et al. Biochem J 411:211–226, 2008). Recently, NRPs have been shown to play novel roles in the tumour stem cell niche and in regulation of tumour immunity. This chapter focuses on the role of NRPs in tumour angiogenesis and tumour progression, focusing on the role of the NRPs as modulators of VEGF function and highlighting approaches to therapeutic targeting of NRPs in cancer.

Type: Book chapter
Title: The role of the neuropilins in tumour angiogenesis and tumour progression
ISBN-13: 978-3-319-48822-6
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/978-3-319-48824-0_10
Publisher version: https://doi.org/10.1007/978-3-319-48824-0_10
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Vascular Endothelial Growth Factor, Sentinel Lymph Node, iNKT Cell, Lymphatic Endothelial Cell, Vascular Endothelial Growth Factor Signalling
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Pre-clinical and Fundamental Science
URI: https://discovery.ucl.ac.uk/id/eprint/10066334
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