UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

High-Density Lipoprotein Function and Dysfunction in Health and Disease

Chiesa, STC; Charakida, M; (2019) High-Density Lipoprotein Function and Dysfunction in Health and Disease. Cardiovascular Drugs and Therapy 10.1007/s10557-018-06846-w. (In press). Green open access

[img]
Preview
Text
Chiesa_High-Density Lipoprotein Function and Dysfunction in Health and Disease_Proof.pdf - Published version

Download (832kB) | Preview

Abstract

High-density lipoprotein cholesterol (HDL-c) has long been referred to as ‘good cholesterol’ due to its apparent inverse relationship with future CVD risk. More recent research has questioned a causal role for HDL-c in this relationship, however, as both genetic studies and numerous large-scale randomised controlled trials have found no evidence of a cardiovascular protective effect when HDL-c levels are raised. Instead, focus has switched to the functional properties of the HDL particle. Evidence suggests that both the composition and function of HDL may be significantly altered in the context of an inflammatory milieu, transforming the particle from a vasoprotective anti-atherogenic particle to a noxious pro-atherogenic equivalent. This review will summarise evidence relating HDL to CVD risk, explore recent evidence characterising changes in the composition and function of HDL that may occur in chronic inflammatory diseases, and discuss the potential for future HDL-modifying therapeutic interventions.

Type: Article
Title: High-Density Lipoprotein Function and Dysfunction in Health and Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s10557-018-06846-w
Publisher version: https://doi.org/10.1007/s10557-018-06846-w
Language: English
Additional information: © The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/).
Keywords: HDL dysfunction, Inflammation, Atherosclerosis, Cardiovascular disease
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10066188
Downloads since deposit
52Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item