UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

In Vitro Oral Cavity Model for Screening the Disintegration Behavior of Orodispersible Films: A Bespoke Design

Redfearn, A; Scarpa, M; Orlu, M; Hanson, B; (2019) In Vitro Oral Cavity Model for Screening the Disintegration Behavior of Orodispersible Films: A Bespoke Design. Journal of Pharmaceutical Sciences , 108 (5) pp. 1831-1836. 10.1016/j.xphs.2018.12.025. Green open access

[thumbnail of Hanson_In vitro oral cavity model for screening the disintegration behaviour of orodispersible films. A bespoke design_AAM.pdf]
Preview
Text
Hanson_In vitro oral cavity model for screening the disintegration behaviour of orodispersible films. A bespoke design_AAM.pdf

Download (4MB) | Preview

Abstract

The availability of biorelevant methods for the disintegration study of pharmaceutical orodispersible dosage forms is required. The disintegration of orodispersibles should be assessed using in vitro methods that can combine biorelevant volumes of disintegration medium, and mechanical stresses mimicking in vivo conditions. This study proposes an adaptation of a mechanical oral cavity model for the disintegration study of orodispersible films. A periodic compression is applied to the sample in the presence of a biorelevant volume of artificial salivary fluid. Four orodispersible films samples (P1, C1, P2, and C2), differing in polymer type and molecular weight, and Listerine® were tested and filmed during disintegration. An image analysis program was developed for the determination of the volume reduction of the film matrix over time, as a descriptor of film disintegration behaviour. Samples P1, and Listerine® showed a volume reduction at 180s of > 90%, C1, P2, and C2 were 85%, 48%, and 37% respectively. The model was able to detect differences in the disintegration behaviour of the four samples, and results were comparable with the benchmark product. The concept of disintegration behaviour of orodispersible films was introduced for the first time as an informative method for the study of orodispersible dosage form.

Type: Article
Title: In Vitro Oral Cavity Model for Screening the Disintegration Behavior of Orodispersible Films: A Bespoke Design
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.xphs.2018.12.025
Publisher version: https://doi.org/10.1016/j.xphs.2018.12.025
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: oral drug delivery, imaging method(s), drug delivery system(s), polymeric drug carrier(s), polymer chemical degradation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/10066051
Downloads since deposit
115Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item