UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

No effect of test and treat on sexual behaviours at population level in rural South Africa

Rolland, M; McGrath, N; Tiendrebeogo, T; Larmarange, J; Pillay, D; Dabis, F; Orne-Gliemann, J; (2019) No effect of test and treat on sexual behaviours at population level in rural South Africa. AIDS , 33 (4) pp. 709-722. 10.1097/QAD.0000000000002104. Green open access

[thumbnail of No_effect_of_test_and_treat_on_sexual_behaviours.97016.pdf]
Preview
Text
No_effect_of_test_and_treat_on_sexual_behaviours.97016.pdf - Accepted Version

Download (925kB) | Preview

Abstract

CONTEXT: Within the community-randomised ANRS 12249 Treatment-as-Prevention (TasP) trial conducted in rural South Africa, we analysed sexual behaviours stratified by sex over time, comparing immediate ART irrespective of CD4 count vs CD4-guided ART (start at CD4>350 then >500) arms. METHODS: As part of the 6-monthly home-based trial rounds, a sexual behaviour questionnaire (IQ) was administered to all residents ≥16 years. We considered seven indicators: sexual intercourse in the past month; at least one regular sexual partner in the past six months; at least one casual sexual partner in the past six months and more than one sexual partner in the past six months; condom use at last sex (CLS) with regular partner, CLS with casual partner, and point prevalence estimate of concurrency. We conducted repeated cross-sectional analyses, stratified by sex. GEE models were used, including trial arm, trial time, calendar time and interaction between trial arm and trial time. RESULTS: CLS with regular partner varied between 29%-51% and 23%- 46% for men and women, respectively, with significantly lower odds among women in the control versus intervention arm by trial end (p < 0.001). CLS with casual partner among men showed a significant interaction between arm and trial round, with no consistent pattern. Women declared more than one partner in the past 6 months in less that 1% of IQs; among men, rates varied between 5%-12%, and odds significantly and continuously declined between calendar rounds 1 and 7 (OR = 4.2 [3.24-5.45]). CONCLUSION: Universal Test and Treat was not associated with increased sexual risk behaviours.

Type: Article
Title: No effect of test and treat on sexual behaviours at population level in rural South Africa
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1097/QAD.0000000000002104
Publisher version: https://doi.org/10.1097/QAD.0000000000002104
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Africa, antiretroviral therapy, HIV, prevention, sexual behaviour
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
URI: https://discovery.ucl.ac.uk/id/eprint/10065906
Downloads since deposit
49Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item