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Statins in Peripheral Arterial Disease

Chiesa, ST; Papageorgiou, N; Charakida, M; (2017) Statins in Peripheral Arterial Disease. Current Pharmaceutical Design , 23 (46) pp. 7099-7108. 10.2174/1381612823666170926130826. Green open access

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Abstract

Peripheral arterial disease (PAD) is a common atherosclertico condition affecting the lower extremities. PAD patients share similar cardiovascular risk factors to coronary artery disease patients and suffer from increased cardiovascular morbidity and mortality. Statins have been widely used in coronary artery disease patients but have been underused in patients with PAD. In the current review, we present data which support the beneficial role of statins in both reducing cardiovascular events and improving symptom-related outcomes in PAD patients. Alongside their lipid lowering effects, their pleiotropic actions are also discussed. Recent guidelines, which strongly recommend the administration of statins in PAD patients, are also presented.

Type: Article
Title: Statins in Peripheral Arterial Disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.2174/1381612823666170926130826
Publisher version: https://doi.org/10.2174/1381612823666170926130826
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Statins, outcomes, peripheral arterial disease, pleiotropic effects, atherosclertico condition.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Clinical Science
URI: https://discovery.ucl.ac.uk/id/eprint/10065752
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