UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Reference curves for the Australian/Canadian Hand Osteoarthritis Index in the middle-aged Dutch population

Kroon, FPB; Ramiro, S; Royston, P; Le Cessie, S; Rosendaal, FR; Kloppenburg, M; (2017) Reference curves for the Australian/Canadian Hand Osteoarthritis Index in the middle-aged Dutch population. Rheumatology , 56 (5) pp. 745-752. 10.1093/rheumatology/kew483. Green open access

[thumbnail of Royston AAM  Reference curves for AUSCAN in NEO_ManuscriptRheumatology_revision_clean.pdf]
Preview
Text
Royston AAM Reference curves for AUSCAN in NEO_ManuscriptRheumatology_revision_clean.pdf - Published Version

Download (1MB) | Preview

Abstract

Objective. The aim was to establish reference curves of the Australian/Canadian Hand Osteoarthritis Index (AUSCAN), a widely used questionnaire assessing hand complaints. Methods. Analyses were performed in a population-based sample, The Netherlands Epidemiology of Obesity study (n = 6671, aged 45–65 years). Factors associated with AUSCAN scores were analysed with ordered logistic regression, because AUSCAN data were zero inflated, dividing AUSCAN into three categories (0 vs 1–5 vs >5). Age- and sex-specific reference curves for the AUSCAN (range 0–60; higher is worse) were developed using quantile regression in conjunction with fractional polynomials. Observed scores in relevant subgroups were compared with the reference curves. Results. The median age was 56 [interquartile range (IQR): 50–61] years; 56% were women and 12% had hand OA according to ACR criteria. AUSCAN scores were low (median 1; IQR: 0–4). Reference curves where higher for women, and increased moderately with age: 95% percentiles for AUSCAN in men and women were, respectively, 5.0 and 12.3 points for a 45-year-old, and 15.2 and 33.6 points for a 65-year-old individual. Additional associated factors included hand OA, inflammatory rheumatic diseases, FM, socio-economic status and BMI. Median AUSCAN pain subscale scores of women with hand OA lay between the 75th and 90th centiles of the general population. Conclusion. AUSCAN scores in the middle-aged Dutch population were low overall, and higher in women than in men. AUSCAN reference curves could serve as a benchmark in research and clinical practice settings. However, the AUSCAN does not measure hand complaints specific for hand OA.

Type: Article
Title: Reference curves for the Australian/Canadian Hand Osteoarthritis Index in the middle-aged Dutch population
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/rheumatology/kew483
Publisher version: https://doi.org/10.1093/rheumatology/kew483
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Hand osteoarthritis, outcomes research, epidemiology
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL
URI: https://discovery.ucl.ac.uk/id/eprint/10065686
Downloads since deposit
75Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item