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Updating Our Definitions of Parkinson's Disease for a Molecular Age

Chen-Plotkin, AS; Zetterberg, H; (2018) Updating Our Definitions of Parkinson's Disease for a Molecular Age. Journal of Parkinson's Disease , 8 (s1) S53-S57. 10.3233/JPD-181487. Green open access

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Abstract

Clinical definitions of Parkinson's disease (PD) are over 200 years old, while neuropathological definitions- which are still the basis of how we define the disease now- are over 100 years old. We argue that for both clinical care and therapeutic development, these definitions need updating for the molecular age in which we live. We highlight specific instances in which genetic or biochemical biomarkers are increasingly used for clinical trial enrollment in the neurodegenerative diseases, suggesting that molecular definition(s) of PD are already emerging. We review candidate biomarkers for PD-related pathologies and highlight the need for further validation.

Type: Article
Title: Updating Our Definitions of Parkinson's Disease for a Molecular Age
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.3233/JPD-181487
Publisher version: http://doi.org/10.3233/JPD-181487
Language: English
Additional information: Copyright © 2018 – IOS Press and the authors. All rights reserved This article is published online with Open Access and distributed under the terms of the Creative Commons Attribution Non-Commercial License (CC BY-NC 4.0).
Keywords: Alpha-synuclein, Parkinson’s disease, biomarkers, genetic subtypes
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10065596
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