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Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer.

Lyon, PC; Winter, H; Herbschleb, K; Campo, L; Carlisle, R; Wu, F; Goldin, R; ... Sharma, RA; + view all (2018) Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer. Radiology Case Reports , 13 (6) pp. 1259-1266. 10.1016/j.radcr.2018.08.020. Green open access

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Abstract

Liver metastasis from breast cancer is associated with poor prognosis and is a major cause of early morbidity and mortality. When liver resection is not feasible, minimally invasive directed therapies are considered to attempt to prolong survival. Selective internal radiation therapy (SIRT) with yttrium-90 microspheres is a liver-directed therapy that can improve local control of liver metastases from colorectal cancer. We present a case of a patient with a ductal breast adenocarcinoma, who developed liver and bone metastasis despite extensive treatment with systemic chemotherapies. Following SIRT to the liver, after an initial response, the patient ultimately progressed in the liver after 7 months. Liver tumor histology obtained 20 months after the SIRT intervention demonstrated the presence of the resin microspheres in situ. This case report demonstrates the long-term control that may be achieved with SIRT to treat liver metastases from breast cancer that is refractory to previous chemotherapies, and the presence of microspheres in situ long-term.

Type: Article
Title: Long-term radiological and histological outcomes following selective internal radiation therapy to liver metastases from breast cancer.
Location: Netherlands
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.radcr.2018.08.020
Publisher version: https://doi.org/10.1016/j.radcr.2018.08.020
Language: English
Additional information: © 2018 The Authors. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Keywords: Liver-directed therapy, SIRT, Selective internal radiation therapy, Transarterial radioembolization
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
URI: https://discovery.ucl.ac.uk/id/eprint/10065563
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