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fMRI reveals neural activity overlap between adult and infant pain

Goksan, S; Hartley, C; Emery, F; Cockrill, N; Poorun, R; Moultrie, F; Rogers, R; ... Slater, R; + view all (2015) fMRI reveals neural activity overlap between adult and infant pain. eLife , 2015 (4) , Article e06356. 10.7554/eLife.06356.001. Green open access

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Abstract

Limited understanding of infant pain has led to its lack of recognition in clinical practice. While the network of brain regions that encode the affective and sensory aspects of adult pain are well described, the brain structures involved in infant nociceptive processing are less well known, meaning little can be inferred about the nature of the infant pain experience. Using fMRI we identified the network of brain regions that are active following acute noxious stimulation in newborn infants, and compared the activity to that observed in adults. Significant infant brain activity was observed in 18 of the 20 active adult brain regions but not in the infant amygdala or orbitofrontal cortex. Brain regions that encode sensory and affective components of pain are active in infants, suggesting that the infant pain experience closely resembles that seen in adults. This highlights the importance of developing effective pain management strategies in this vulnerable population.

Type: Article
Title: fMRI reveals neural activity overlap between adult and infant pain
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.06356.001
Publisher version: https://doi.org/10.7554/eLife.06356.001
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education
UCL > Provost and Vice Provost Offices > School of Education > UCL Institute of Education > IOE - Culture, Communication and Media
URI: https://discovery.ucl.ac.uk/id/eprint/10065549
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