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Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct

Leira, Y; Rodríguez-Yáñez, M; Arias, S; López-Dequidt, I; Campos, F; Sobrino, T; D'Aiuto, F; ... Blanco, J; + view all (2019) Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct. Journal of Clinical Periodontology , 46 (1) pp. 20-30. 10.1111/jcpe.13032. Green open access

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Abstract

AIM: To investigate the association between periodontitis (PD) and lacunar infarct (LI) as well as to analyse whether PD could be a predictor of poor functional prognosis in patients with LI. MATERIAL AND METHODS: Full-mouth periodontal examination was done in 120 cases (patients with LI) and 157 healthy controls. Demographic, clinical, medical and neurological information were collected from all of them. In addition, a measure of periodontal inflammation and disease activity, namely the periodontal inflamed surface area (PISA), was also calculated for each patient. Poor functional outcome was considered as a modified Rankin Scale >2 at 3 months. RESULTS: PD was independently associated with the presence of LI (OR = 3.3, p < 0.001). Poor outcome was observed in 31 patients with LI (25.8%), of which 90.3% had PD. A PISA value ≥727 mm2 was an independent predictor of poor prognosis, after adjusting for clinical confounders (OR = 6.5, p = 0.001). CONCLUSIONS: PD and LI were associated. Active moderate to severe PD predicted poor prognosis in patients with LI. Further evidence is warranted to confirm our results and investigate potential mechanisms behind this association.

Type: Article
Title: Periodontitis as a risk indicator and predictor of poor outcome for lacunar infarct
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/jcpe.13032
Publisher version: https://doi.org/10.1111/jcpe.13032
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: lacunar infarct, periodontal inflamed surface area, periodontitis, predictors, prognosis, stroke
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/10065544
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