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Antenatal vaccination against Group B streptococcus: attitudes of pregnant women and healthcare professionals in the UK towards participation in clinical trials and routine implementation

McQuaid, F; Jones, C; Stevens, Z; Meddaugh, G; O'Sullivan, C; Donaldson, B; Hughes, R; ... Snape, MD; + view all (2018) Antenatal vaccination against Group B streptococcus: attitudes of pregnant women and healthcare professionals in the UK towards participation in clinical trials and routine implementation. Acta Obstetricia et Gynecologica Scandinavica , 97 (3) pp. 330-340. 10.1111/aogs.13288. Green open access

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Abstract

Introduction : Maternal vaccination is increasingly part of antenatal care in the UK and worldwide. Trials of Group B streptococcus (GBS) vaccines are ongoing. This study investigated the attitudes of pregnant women and healthcare profe ssionals towards antenatal vaccination, both in routine care and a clinical trial setting. Material and methods : Survey of 269 pregnant women, 273 midwives/obstetricians and 97 neonatal doctors across seven sites in the UK assessing attitudes towards antenatal vaccinations, knowledge of GBS, a hypothetical GBS vaccine and participation in clinical vaccine trials. Results : Sixty -eight percent of pregnant women intended to receive a vaccine during their current pregnancy (183/269) and 43% (of all respondents, 115/269) reported they would be very/fairly likely to accept a vaccine against GBS despite only 29% (55/269) knowing what GBS was. This increased to 69% after additional information about GBS was provided. Twenty -four percent of pregnant women reported they would be likely to take part in a clinical trial of an unlicensed GBS vaccine. Fifty -nine percent of maternity professionals and 74% of neonatologists would be likely to recommend participation in a GBS vaccine trial to women , with the vast majority (>99%) willing to be involved in such a study . Incentives to take part cited by pregnant women included extra antenatal scans and the opportunity to be tested for GBS. Conclusion : Pregnant women and healthcare professionals were open to the idea of an antenatal GBS vaccine and involvement in clinical trials of such a vaccine. Education and support from midwives would be key to successful implementation.

Type: Article
Title: Antenatal vaccination against Group B streptococcus: attitudes of pregnant women and healthcare professionals in the UK towards participation in clinical trials and routine implementation
Open access status: An open access version is available from UCL Discovery
DOI: 10.1111/aogs.13288
Publisher version: http://doi.org/10.1111/aogs.13288
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Group B streptococcus, antenatal vaccine, pregnancy, attitudes, healthcare professionals, pregnant women, clinical trials
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/10065437
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