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The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults

Poisnel, G; Arenaza-Urquijo, E; Collette, F; Klimecki, OM; Marchant, NL; Wirth, M; de La Sayette, V; ... Medit-Ageing Research Group, .; + view all (2018) The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults. Alzheimer's & Dementia: Translational Research & Clinical Interventions , 4 pp. 714-723. 10.1016/j.trci.2018.10.011. Green open access

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Abstract

INTRODUCTION: The Age-Well clinical trial is an ongoing monocentric, randomized, controlled trial aiming to assess an 18-month preventive meditation-based intervention directly targeting the attentional and emotional dimensions of aging to promote mental health and well-being in elderly people. METHODS: One hundred thirty-seven cognitively unimpaired older adults are randomized to either an 18-month meditation-based intervention, a structurally matched foreign language training, or a passive control arm. The impact of the intervention and underlying mechanisms are assessed with detailed cognitive, behavioral, biological, neuroimaging and sleep examinations. RESULTS: Recruitment began in late 2016 and ended in May 2018. The interventions are ongoing and will be completed by early 2020. DISCUSSION: This is the first trial addressing the emotional and cognitive dimension of aging with a long-term nonpharmacological approach and using comprehensive assessments to investigate the mechanisms. Results are expected to foster the development of preventive strategies reducing the negative impact of mental conditions and disorders.

Type: Article
Title: The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.trci.2018.10.011
Publisher version: https://doi.org/10.1016/j.trci.2018.10.011
Language: English
Additional information: © 2018 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Aging, Alzheimer's disease, Attention, Blood markers, Cognition, Compassion, Dementia, Emotion, Foreign language training, Lifestyle, Meditation, Mindfulness, Neuroimaging, Prevention, Reserve, Sleep
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/10065254
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