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Remote Memory and the Hippocampus: A Constructive Critique

Barry, DN; Maguire, EA; (2019) Remote Memory and the Hippocampus: A Constructive Critique. Trends in Cognitive Sciences , 23 (2) pp. 128-142. 10.1016/j.tics.2018.11.005. Green open access

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Abstract

The hippocampus is known to be recruited during the recall of experiences from our distant past, despite evidence that memory traces in this region vanish over time. Extant theories of systems-level consolidation have yet to accommodate both phenomena. We propose that the hippocampus reconstructs remote memories in the absence of the original trace. It accomplishes this by assembling consolidated neocortical elements into spatially coherent scenes that form the basis of unfolding memory events. This reconstruction is likely facilitated by input from the ventromedial prefrontal cortex. This process-oriented approach to hippocampal recruitment during remote recollection is consistent with its increasingly acknowledged role in constructing mental representations beyond the domain of memory.

Type: Article
Title: Remote Memory and the Hippocampus: A Constructive Critique
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.tics.2018.11.005
Publisher version: https://doi.org/10.1016/j.tics.2018.11.005
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: episodic memory, reconstruction, scenes, systems-level consolidation, vmPFC
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Experimental Psychology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Imaging Neuroscience
URI: https://discovery.ucl.ac.uk/id/eprint/10065031
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