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New approaches for the treatment of Alzheimer's disease

Fish, PV; Steadman, D; Bayle, ED; Whiting, P; (2019) New approaches for the treatment of Alzheimer's disease. Bioorganic & Medicinal Chemistry Letters , 29 (2) pp. 125-133. 10.1016/j.bmcl.2018.11.034. Green open access

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Abstract

Alzheimer's disease (AD) is the most prevalent chronic neurodegenerative disease. Current approved therapies are symptomatic treatments having some effect on cognitive function. Therapies that target β-amyloid (Aβ) have been the focus of efforts to develop a disease modification treatment for AD but these approaches have failed to show any clinical benefit so far. Beyond the 'Aβ hypothesis', there are a number of newer approaches to treat AD with neuroinflammation emerging as a very active area of research based on risk gene analysis. This short review will summarize approved drug therapies, recent clinical trials and new approaches for the treatment of AD.

Type: Article
Title: New approaches for the treatment of Alzheimer's disease
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bmcl.2018.11.034
Publisher version: https://doi.org/10.1016/j.bmcl.2018.11.034
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Alzheimer’s disease, Disease modification, Drug discovery pipeline, Neurodegeneration, Neuroinflammation, Symptomatic treatments
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10065008
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