Fish, PV;
Steadman, D;
Bayle, ED;
Whiting, P;
(2019)
New approaches for the treatment of Alzheimer's disease.
Bioorganic & Medicinal Chemistry Letters
, 29
(2)
pp. 125-133.
10.1016/j.bmcl.2018.11.034.
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AD Digest for BMCL - version for UCL Discovery.pdf - Accepted Version Download (1MB) | Preview |
Abstract
Alzheimer's disease (AD) is the most prevalent chronic neurodegenerative disease. Current approved therapies are symptomatic treatments having some effect on cognitive function. Therapies that target β-amyloid (Aβ) have been the focus of efforts to develop a disease modification treatment for AD but these approaches have failed to show any clinical benefit so far. Beyond the 'Aβ hypothesis', there are a number of newer approaches to treat AD with neuroinflammation emerging as a very active area of research based on risk gene analysis. This short review will summarize approved drug therapies, recent clinical trials and new approaches for the treatment of AD.
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