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Acute-on-chronic liver failure in patients with alcohol-related liver disease

Gustot, T; Kamath, P; Jalan, R; (2019) Acute-on-chronic liver failure in patients with alcohol-related liver disease. Journal of Hepatology , 70 (2) pp. 319-327. 10.1016/j.jhep.2018.12.008. Green open access

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Abstract

The spectrum of alcohol-related liver diseases (ALD) includes steatosis, steatohepatitis, progressive liver fibrosis, and cirrhosis. Acute-on-chronic liver failure (ACLF) is a recently defined entity that occurs in patients with chronic liver diseases and is characterised by acute decompensation, organ failures and a high risk of short-term mortality. Active alcohol consumption, alcoholic hepatitis and bacterial infections are the most frequent events precipitating the development of ACLF in the context of ALD (ALD-ACLF). The specific management of this entity remains unknown and the place of salvage liver transplantation controversial. This overview details the current knowledge on specific aspects of epidemiology, pathophysiology, prognosis and management of ALD-ACLF.

Type: Article
Title: Acute-on-chronic liver failure in patients with alcohol-related liver disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.jhep.2018.12.008
Publisher version: https://doi.org/10.1016/j.jhep.2018.12.008
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Cirrhosis, Organ failure, Inflammation, Alcoholic hepatitis, Infection, Liver transplantation
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inst for Liver and Digestive Hlth
URI: https://discovery.ucl.ac.uk/id/eprint/10064967
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