Villaluz, MM;
Lomax, LB;
Jadhav, T;
Cross, JH;
Scheffer, IE;
(2018)
The ketogenic diet is effective for refractory epilepsy associated with acquired structural epileptic encephalopathy.
Developmental Medicine and Child Neurology
, 60
(7)
pp. 718-723.
10.1111/dmcn.13687.
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Abstract
AIM: Ketogenic diet therapies have proven efficacy for refractory epilepsy. There are many reports of their use in the genetic developmental and epileptic encephalopathies; however, little attention has been paid as to whether the diet is also effective in individuals with an acquired structural aetiology. We observed remarkable efficacy of the diet in two patients with hypoxic‐ischaemic encephalopathy. We then analysed our cases with refractory structural epilepsies of acquired origin to characterize their response to the ketogenic diet. METHOD: The classical ketogenic diet was implemented with dietary ratios of 3:1 to 4.4:1. Seizure frequency at 1 month, 3 months, 6 months, 1 year, and 2 years was ascertained. A responder was defined as greater than 50% seizure reduction compared to baseline. RESULTS: Seven of the nine patients were responders at 3 months. INTERPRETATION: Somewhat surprisingly we found that the ketogenic diet was effective in patients with a developmental and epileptic encephalopathy due to an acquired structural aetiology. This cohort may not be routinely considered for the ketogenic diet because of their structural and acquired, rather than genetic, basis. The ketogenic diet should be considered early in the management of patients with acquired structural encephalopathies as it can improve seizure control with the potential to improve developmental outcome. WHAT THIS PAPER ADDS: The ketogenic diet was effective in children with epilepsy associated with an acquired structural aetiology.
| Type: | Article |
|---|---|
| Title: | The ketogenic diet is effective for refractory epilepsy associated with acquired structural epileptic encephalopathy |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/dmcn.13687 |
| Publisher version: | https://doi.org/10.1111/dmcn.13687 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064811 |
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