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No association of salivary total tau concentration with Alzheimer's disease

Ashton, NJ; Ide, M; Scholl, M; Blennow, K; Lovestone, S; Hye, A; Zetterberg, H; (2018) No association of salivary total tau concentration with Alzheimer's disease. Neurobiology of Aging , 70 pp. 125-127. 10.1016/j.neurobiolaging.2018.06.014. Green open access

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Abstract

There is a need for an accessible biomarker that can complement current cerebrospinal fluid and imaging biomarkers in an accurate and early diagnosis of Alzheimer disease (AD). Saliva is a rich source of potential biomarkers and proteins related to neurodegenerative disorders have been shown to be present in this matrix, including tau. In this study, we quantified salivary total tau (t-tau) concentration in 160 healthy elderly control, 68 mild cognitive impairment, and 53 AD participants using ultrasensitive Single molecule array (Simoa) technology. No median difference in salivary t-tau concentration was found between AD and mild cognitive impairment or healthy elderly control (12.3 ng/L, 9.8 ng/L and 9.6 ng/L, respectively, p = 0.219). In addition, there was no association of salivary t-tau concentration with neurophysiological assessment or structural magnetic resonance imaging. Despite a nominal increase in AD, due to the large overlaps in concentrations between clinical groups, we conclude that salivary t-tau is a suitable biomarker neither for AD nor for cognitive impairment.

Type: Article
Title: No association of salivary total tau concentration with Alzheimer's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neurobiolaging.2018.06.014
Publisher version: http://doi.org/10.1016/j.neurobiolaging.2018.06.01...
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Biomarkers, Fluid-biomarkers, Alzheimer’s disease, Saliva, Tau, Diagnosis, Immunoassays
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10064641
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