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Update on biomarkers for amyloid pathology in Alzheimer's disease

Ashton, NJ; Schoell, M; Heurling, K; Gkanatsiou, E; Portelius, E; Hoeglund, K; Brinkmalm, G; ... Zetterberg, H; + view all (2018) Update on biomarkers for amyloid pathology in Alzheimer's disease. Biomarkers in Medicine , 12 (7) pp. 799-812. 10.2217/bmm-2017-0433. Green open access

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Abstract

At the center of Alzheimer's disease pathogenesis is the aberrant aggregation of amyloid-β (Aβ) into oligomers, fibrils and plaques. Effective monitoring of Aβ deposition directly in patients is essential to assist anti-Aβ therapeutics in target engagement and participant selection. In the advent of approved anti-Aβ therapeutics, biomarkers will become of fundamental importance in initiating treatments having disease modifying effects at the earliest stage. Two well-established Aβ biomarkers are widely utilized: Aβ-binding ligands for positron emission tomography and immunoassays to measure Aβ42 in cerebrospinal fluid. In this review, we will discuss the current clinical, diagnostic and research state of biomarkers for Aβ pathology. Furthermore, we will explore the current application of blood-based markers to assess Aβ pathology.

Type: Article
Title: Update on biomarkers for amyloid pathology in Alzheimer's disease
Open access status: An open access version is available from UCL Discovery
DOI: 10.2217/bmm-2017-0433
Publisher version: http://doi.org/10.2217/bmm-2017-0433
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Aβ, Alzheimer's disease, amyloid-β, biomarkers, blood-based biomarkers, cerebrospinal fluid, dementia, positron emission tomography
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/10064636
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