Carnevali, PBM;
Schulz, F;
Castelle, C;
Kantor, R;
Shih, P;
Sharon, I;
Santini, JM;
... Banfield, JF; + view all
(2019)
Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria.
Nature Communications
, 10
, Article 463. 10.1038/s41467-018-08246-y.
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Abstract
The evolution of aerobic respiration was likely linked to the origins of oxygenic Cyanobacteria. Close phylogenetic neighbors to Cyanobacteria, such as Margulisbacteria (RBX-1 and ZB3), Saganbacteria (WOR-1), Melainabacteria and Sericytochromatia, may constrain the metabolic platform in which aerobic respiration arose. Here, we analyze genomic sequences and predict that sediment-associated Margulisbacteria have a fermentation-based metabolism featuring a variety of hydrogenases, a streamlined nitrogenase, and electron bifurcating complexes involved in cycling of reducing equivalents. The genomes of ocean-associated Margulisbacteria encode an electron transport chain that may support aerobic growth. Some Saganbacteria genomes encode various hydrogenases, and others may be able to use O2 under certain conditions via a putative novel type of heme copper O2 reductase. Similarly, Melainabacteria have diverse energy metabolisms and are capable of fermentation and aerobic or anaerobic respiration. The ancestor of all these groups may have been an anaerobe in which fermentation and H2 metabolism were central metabolic features. The ability to use O2 as a terminal electron acceptor must have been subsequently acquired by these lineages.
| Type: | Article |
|---|---|
| Title: | Hydrogen-based metabolism as an ancestral trait in lineages sibling to the Cyanobacteria |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41467-018-08246-y |
| Publisher version: | https://doi.org/10.1038/s41467-018-08246-y |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Bacterial evolution, Bacterial physiology, Functional genomics, Metagenomics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Structural and Molecular Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064568 |
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