Marghoub, A;
Libby, J;
Babbs, C;
Ventikos, Y;
Fagan, MJ;
Moazen, M;
(2019)
Characterizing and Modeling Bone Formation during Mouse Calvarial Development.
Physical Review Letters
, 122
(4)
, Article 048103. 10.1103/PhysRevLett.122.048103.
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Abstract
The newborn mammalian cranial vault consists of five flat bones that are joined together along their edges by soft fibrous tissues called sutures. Early fusion of these sutures leads to a medical condition known as craniosynostosis. The mechanobiology of normal and craniosynostotic skull growth is not well understood. In a series of previous studies, we characterized and modeled radial expansion of normal and craniosynostotic (Crouzon) mice. Here, we describe a new modeling algorithm to simulate bone formation at the sutures in normal and craniosynostotic mice. Our results demonstrate that our modeling approach is capable of predicting the observed ex vivo pattern of bone formation at the sutures in the aforementioned mice. The same approach can be used to model different calvarial reconstruction in children with craniosynostosis to assist in the management of this complex condition.
| Type: | Article |
|---|---|
| Title: | Characterizing and Modeling Bone Formation during Mouse Calvarial Development |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1103/PhysRevLett.122.048103 |
| Publisher version: | https://doi.org/10.1103/PhysRevLett.122.048103 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Polymers & Soft Matter, Biological Physics, Interdisciplinary Physics |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064522 |
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