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Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence

Xu, W; Monaco, G; Wong, EH; Tan, WLW; Kared, H; Simoni, Y; Tan, SW; ... Larbi, A; + view all (2019) Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence. EBioMedicine 10.1016/j.ebiom.2018.11.053. (In press). Green open access

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Abstract

Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ T cells have been neglected despite their role in immunosurveillance. We investigated the impact of aging on γδ T cell subsets phenotypes, functions, senescence and their molecular response to stress. Methods: Peripheral blood of young and old donors in Singapore have been used to assess the phenotype, functional capacity, proliferation capacity and gene expression of the various γδ T cell subsets. Peripheral blood mononuclear cells from apheresis cones and young donors have been used to characterize the telomere length, epigenetics profile and DNA damage response of the various γδ T cell subsets phenotype. Findings: Our data shows that peripheral Vδ2+ phenotype, functional capacity (cytokines, cytotoxicity, proliferation) and gene expression profile are specific when compared against all other αβ and γδ T cells in aging. Hallmarks of senescence including telomere length, epigenetic profile and DNA damage response of Vδ2+ also differs against all other αβ and γδ T cells. Interpretation: Our results highlight the differential impact of lifelong stress on γδ T cells subsets, and highlight possible mechanisms that enable Vδ2+ to be resistant to cellular aging. The new findings reinforce the concept that Vδ2+ have an “innate-like” behavior and are more resilient to the environment as compared to “adaptive-like” Vδ1+ T cells.

Type: Article
Title: Mapping of γ/δ T cells reveals Vδ2+ T cells resistance to senescence
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ebiom.2018.11.053
Publisher version: https://doi.org/10.1016/j.ebiom.2018.11.053
Language: English
Additional information: Copyright © 2018. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Gamma Delta T cells, Immunosenescence, Innate Immunity, Immunobiology, Aging, Cellular Senescence
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/10064442
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