Nestor, PJ;
Altomare, D;
Festari, C;
Drzezga, A;
Rivolta, J;
Walker, Z;
Bouwman, F;
... Frisoni, GB; + view all
(2018)
Clinical utility of FDG-PET for the differential diagnosis among the main forms of dementia.
European Journal of Nuclear Medicine and Molecular Imaging
, 45
(9)
pp. 1509-1525.
10.1007/s00259-018-4035-y.
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Abstract
Aim: To assess the clinical utility of FDG-PET as a diagnostic aid for differentiating Alzheimer’s disease (AD; both typical and atypical forms), dementia with Lewy bodies (DLB), frontotemporal lobar degeneration (FTLD), vascular dementia (VaD) and non-degenerative pseudodementia. Methods: A comprehensive literature search was conducted using the PICO model to extract evidence from relevant studies. An expert panel then voted on six different diagnostic scenarios using the Delphi method. Results: The level of empirical study evidence for the use of FDG-PET was considered good for the discrimination of DLB and AD; fair for discriminating FTLD from AD; poor for atypical AD; and lacking for discriminating DLB from FTLD, AD from VaD, and for pseudodementia. Delphi voting led to consensus in all scenarios within two iterations. Panellists supported the use of FDG-PET for all PICOs—including those where study evidence was poor or lacking—based on its negative predictive value and on the assistance it provides when typical patterns of hypometabolism for a given diagnosis are observed. Conclusion: Although there is an overall lack of evidence on which to base strong recommendations, it was generally concluded that FDG-PET has a diagnostic role in all scenarios. Prospective studies targeting diagnostically uncertain patients for assessing the added value of FDG-PET would be highly desirable.
| Type: | Article |
|---|---|
| Title: | Clinical utility of FDG-PET for the differential diagnosis among the main forms of dementia |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1007/s00259-018-4035-y |
| Publisher version: | https://doi.org/10.1007/s00259-018-4035-y |
| Language: | English |
| Additional information: | This version is the version of the record. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | FDG-PET, Alzheimer’s disease, Atypical Alzheimer, Dementia with Lewy bodies, Frontotemporal lobar degeneration, Vascular dementia, Pseudodementia, PICO, Delphi |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064429 |
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