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Peptide functionalized dual-responsive chitosan nanoparticles for controlled drug delivery to breast cancer cells

Qian, Q; Niu, S; Williams, GR; Wu, J; Zhang, X; Zhu, L; (2019) Peptide functionalized dual-responsive chitosan nanoparticles for controlled drug delivery to breast cancer cells. Colloids and Surfaces A: Physicochemical and Engineering Aspects , 564 pp. 122-130. 10.1016/j.colsurfa.2018.12.026. Green open access

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Abstract

In this work, we report K237-peptide functionalized chitosan (CS) nanoparticles (NPs) loaded with paclitaxel (PTX), for active targeting and effective treatment of KDR/Flk-1-overexpressing human breast cancer. The results displayed that the peptide-functionalized NPs put up favorable pH and temperature-sensitive characteristics. MTT assays showed that K237-CS (PTX)-g-PNIPAM NPs had a more peculiar and effective breast cancer cell growth inhibition compared with peptide-free NPs. Confocal experiments showed that the NPs could precisely target MDA-MB-231 human breast cancer cells which were over-expressing KDR/Flk-1 and could be effectively internalized into MDA-MB-231 cells, which verified that the uptake of FITC-K237-CS (PTX)-g-PNIPAM NPs was associated with KDR/Flk-1 on the breast cancer cell. These results indicate that the peptide functionalized NPs have potential applications for targeted delivery and the controlled release of anticancer drugs.

Type: Article
Title: Peptide functionalized dual-responsive chitosan nanoparticles for controlled drug delivery to breast cancer cells
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.colsurfa.2018.12.026
Publisher version: https://doi.org/10.1016/j.colsurfa.2018.12.026
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: K237-peptide, dual-responsive, nanoparticles, targeted delivery, human breast cancer
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery.ucl.ac.uk/id/eprint/10064414
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