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On heuristic bias in fragment-Assembly methods for protein structure prediction

Handl, J; Garza-Fabre, M; Kandathil, S; Lovell, SC; (2017) On heuristic bias in fragment-Assembly methods for protein structure prediction. In: Proceedings of the Genetic and Evolutionary Computation Conference Companion : GECCO '17. (pp. pp. 1652-1656). ACM: Berlin, Germany. Green open access

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Abstract

We discuss the issue of heuristic bias in fragment-Assembly methods for protein structure prediction. We explain the importance of this issue, which has been paid insufficient a.ention by evolutionary computation researchers engaging with the structural biology community. We proceed by describing preliminary data that illustrates the signi.cant (and expectable) impact that fragment library composition has on search performance, and discuss the challenges this poses for the development of improved fragment libraries.

Type: Proceedings paper
Title: On heuristic bias in fragment-Assembly methods for protein structure prediction
Event: Genetic and Evolutionary Computation Conference Companion : GECCO '17
ISBN-13: 9781450349390
Open access status: An open access version is available from UCL Discovery
DOI: 10.1145/3067695.3082545
Publisher version: https://doi.org/10.1145/3067695.3082545
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Protein Structure Prediction, Fragment-assembly, Heuristic Bias
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/10064122
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