Handl, J;
Garza-Fabre, M;
Kandathil, S;
Lovell, SC;
(2017)
On heuristic bias in fragment-Assembly methods for protein structure prediction.
In:
Proceedings of the Genetic and Evolutionary Computation Conference Companion : GECCO '17.
(pp. pp. 1652-1656).
ACM: Berlin, Germany.
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Abstract
We discuss the issue of heuristic bias in fragment-Assembly methods for protein structure prediction. We explain the importance of this issue, which has been paid insufficient a.ention by evolutionary computation researchers engaging with the structural biology community. We proceed by describing preliminary data that illustrates the signi.cant (and expectable) impact that fragment library composition has on search performance, and discuss the challenges this poses for the development of improved fragment libraries.
| Type: | Proceedings paper |
|---|---|
| Title: | On heuristic bias in fragment-Assembly methods for protein structure prediction |
| Event: | Genetic and Evolutionary Computation Conference Companion : GECCO '17 |
| ISBN-13: | 9781450349390 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1145/3067695.3082545 |
| Publisher version: | https://doi.org/10.1145/3067695.3082545 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Protein Structure Prediction, Fragment-assembly, Heuristic Bias |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064122 |
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