UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Oculogyric crises: Etiology, pathophysiology and therapeutic approaches

Barow, E; Schneider, SA; Bhatia, KP; Ganos, C; (2016) Oculogyric crises: Etiology, pathophysiology and therapeutic approaches. Parkinsonism & Related Disorders , 36 pp. 3-9. 10.1016/j.parkreldis.2016.11.012. Green open access

[thumbnail of Bhatia OGCFinalRevisionclean_eb.pdf]
Preview
Text
Bhatia OGCFinalRevisionclean_eb.pdf - Accepted version

Download (442kB) | Preview

Abstract

Oculogyric crisis (OGC) describes the clinical phenomenon of sustained dystonic, conjugate and typically upward deviation of the eyes lasting from seconds to hours. It was initially observed in patients with postencephalitic parkinsonism, but since then a number of conditions have been associated with OGC. These include drug-induced reactions, hereditary and sporadic movement disorders, and focal brain lesions. Here, we systematically review the literature and discuss the spectrum of disorders associated with OGC in order to aid clinicians place this rare but distinctive clinical sign into the appropriate diagnostic context. We also provide a brief synthesis of putative pathophysiological mechanisms, as well as therapeutic recommendations based on the literature and our own experience.

Type: Article
Title: Oculogyric crises: Etiology, pathophysiology and therapeutic approaches
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.parkreldis.2016.11.012
Publisher version: https://doi.org/10.1016/j.parkreldis.2016.11.012
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, Oculogyric crisis, Dystonia, Acute dystonic reaction, Drug-induced dystonia, TYROSINE-HYDROXYLASE DEFICIENCY, SEPIAPTERIN REDUCTASE DEFICIENCY, ACID DECARBOXYLASE DEFICIENCY, VESICULAR TRANSPORT DISEASE, DOPA-RESPONSIVE DYSTONIA, MOVEMENT-DISORDERS, BASAL GANGLIA, PARKINSONS-DISEASE, TARDIVE-DYSKINESIA, ONSET PARKINSONISM
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/10064038
Downloads since deposit
1,197Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item