Barow, E;
Schneider, SA;
Bhatia, KP;
Ganos, C;
(2016)
Oculogyric crises: Etiology, pathophysiology and therapeutic approaches.
Parkinsonism & Related Disorders
, 36
pp. 3-9.
10.1016/j.parkreldis.2016.11.012.
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Abstract
Oculogyric crisis (OGC) describes the clinical phenomenon of sustained dystonic, conjugate and typically upward deviation of the eyes lasting from seconds to hours. It was initially observed in patients with postencephalitic parkinsonism, but since then a number of conditions have been associated with OGC. These include drug-induced reactions, hereditary and sporadic movement disorders, and focal brain lesions. Here, we systematically review the literature and discuss the spectrum of disorders associated with OGC in order to aid clinicians place this rare but distinctive clinical sign into the appropriate diagnostic context. We also provide a brief synthesis of putative pathophysiological mechanisms, as well as therapeutic recommendations based on the literature and our own experience.
| Type: | Article |
|---|---|
| Title: | Oculogyric crises: Etiology, pathophysiology and therapeutic approaches |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.parkreldis.2016.11.012 |
| Publisher version: | https://doi.org/10.1016/j.parkreldis.2016.11.012 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Clinical Neurology, Neurosciences & Neurology, Oculogyric crisis, Dystonia, Acute dystonic reaction, Drug-induced dystonia, TYROSINE-HYDROXYLASE DEFICIENCY, SEPIAPTERIN REDUCTASE DEFICIENCY, ACID DECARBOXYLASE DEFICIENCY, VESICULAR TRANSPORT DISEASE, DOPA-RESPONSIVE DYSTONIA, MOVEMENT-DISORDERS, BASAL GANGLIA, PARKINSONS-DISEASE, TARDIVE-DYSKINESIA, ONSET PARKINSONISM |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/10064038 |
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